i’d go for a fender amp (35w plus for the headroom) and humbucker guitar (es 335, or a les paul if you want a more direct sound)
a line 6 delay will give you everything you need in compact box, and an overdrive by j.rockett. I use a phase90 which i like very much.
don’t overcomplicate things with hundreds of buttons. concentrate on the message or feeling with a minimum
bless !